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1

Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies

Gilles Labbe, Dominique Pessayre, Bernard Fromenty

Journal:

Fundamental & Clinical Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 301 KB

english, 2008

2

Central role of mitochondria in drug-induced liver injury

Pessayre, Dominique, Fromenty, Bernard, Berson, Alain, Robin, Marie-Anne, Lettéron, Philippe, Moreau, Richard, Mansouri, Abdellah

Journal:

Drug Metabolism Reviews

Année:

2012

Langue:

english

Fichier:

PDF, 2.60 MB

english, 2012

3

Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

Bernard Fromenty, Dominique Pessayre

Journal:

Pharmacology & Therapeutics

Année:

1995

Langue:

english

Fichier:

PDF, 6.11 MB

english, 1995

4

Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it

Karima Begriche, Anissa Igoudjil, Dominique Pessayre, Bernard Fromenty

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 572 KB

english, 2006

5

Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes

Alain Berson, Virginie De Beco, Philippe Lettéron, Marie Anne Robin, Claire Moreau, Johny El Kahwaji, Nicole Verthier, Gérard Feldmann, Bernard Fromenty, Dominique Pessayre

Journal:

Gastroenterology

Année:

1998

Langue:

english

Fichier:

PDF, 220 KB

english, 1998

6

Microvesicular steatosis and steatohepatitis: role of mitochondrial dysfunction and lipid peroxidation

Bernard Fromenty, Alain Berson, Dominique Pessayre

Journal:

Journal of Hepatology

Année:

1997

Langue:

english

Fichier:

PDF, 964 KB

english, 1997

7

Aggravation des hépatopathies liées à l’obésité par les xénobiotiques

Fromenty, Bernard

Journal:

Nutrition Clinique et Métabolisme

Année:

2014

Langue:

french

Fichier:

PDF, 1.05 MB

french, 2014

8

Gamma-glutamyltransferase, fatty liver index and hepatic insulin resistance are associated with incident hypertension in two longitudinal studies

Bonnet, Fabrice, Gastaldelli, Amalia, Pihan-Le bars, Florence, Natali, Andrea, Roussel, Ronan, Petrie, John, Tichet, Jean, Marre, Michel, Fromenty, Bernard, Balkau, Beverley

Journal:

Journal of Hypertension

Année:

2017

Langue:

english

Fichier:

PDF, 332 KB

english, 2017

9

Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis

Massart, Julie, Begriche, Karima, Fromenty, Bernard

Journal:

Clinics and Research in Hepatology and Gastroenterology

Année:

2020

Fichier:

PDF, 1.32 MB

2020

10

Multikinase inhibitor-induced liver injury in patients with cancer: A review for clinicians

Houron, Camille, Danielou, Marie, Mir, Olivier, Fromenty, Bernard, Perlemuter, Gabriel, Voican, Cosmin Sebastian

Journal:

Critical Reviews in Oncology/Hematology

Année:

2021

Fichier:

PDF, 1.15 MB

2021

11

High proportions of mtDNA duplications in patients with Kearns-Sayre syndrome occur in the heart

Fromenty, Bernard, Carrozzo, Rosalba, Shanske, Sara, Schon, Eric A.

Journal:

American Journal of Medical Genetics

Année:

1997

Langue:

english

Fichier:

PDF, 668 KB

english, 1997

12

Decreased mitochondrial oxidation of fatty acids in pregnant mice: Possible relevance to development of acute fatty liver of pregnancy

Sylvie Grimbert, Bernard Fromenty, Cecile Fisch, Philippe Letteron, Alain Berson, Anne Marie Durand-Schneider, Gerard Feldmann, Dominique Pessayre

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 1.20 MB

english, 1993

13

Inhibition by perhexiline of oxidative phosphorylation and the β-oxidation of fatty acids: Possible role in pseudoalcoholic liver lesions

Dominique Deschamps, Virginie DeBeco, Cecile Fisch, Bernard Fromenty, Andre Guillouzo, Dominique Pessayre

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 1.51 MB

english, 1994

14

Alcohol increases tumor necrosis factor α and decreases nuclear factor-κb to activate hepatic apoptosis in genetically obese mice

Marie-Anne Robin, Christine Demeilliers, Angéla Sutton, Valérie Paradis, Caroline Maisonneuve, Sylvie Dubois, Odile Poirel, Philippe Lettéron, Dominique Pessayre, Bernard Fromenty

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 643 KB

english, 2005

15

Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in heparg cells

Sébastien Anthérieu, Alexandra Rogue, Bernard Fromenty, André Guillouzo, Marie-Anne Robin

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 744 KB

english, 2011

16

Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet

Viviane Trak-Smayra, Valérie Paradis, Julie Massart, Selim Nasser, Victor Jebara, Bernard Fromenty

Journal:

International Journal of Experimental Pathology

Année:

2011

Langue:

english

Fichier:

PDF, 503 KB

english, 2011

17

Effects of β-aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity

Karima Begriche, Julie Massart, Bernard Fromenty

Journal:

Fundamental & Clinical Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 325 KB

english, 2010

18

PREMATURE OXIDATIVE DAMAGE TO HEPATIC MITOCHONDRIAL DNA IN ALCOHOLIC PATIENTS WITH MICROVESICULAR STEATOSIS

Bernard Fromenty, Abdellah Mansouri, Dominique Pessayre

Journal:

Alcoholism: Clinical and Experimental Research

Année:

1998

Langue:

english

Fichier:

PDF, 252 KB

english, 1998

19

Effects of Alcohol and Oxidative Stress on Liver Pathology: The Role of the Mitochondrion

Alan Cahill, Carol C. Cunningham, Masayuki Adachi, Hiromasa Ishii, Shannon M. Bailey, Bernard Fromenty, Adrian Davies

Journal:

Alcoholism: Clinical and Experimental Research

Année:

2002

Langue:

english

Fichier:

PDF, 148 KB

english, 2002

20

Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity

Laetitia Knockaert, Bernard Fromenty, Marie-Anne Robin

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 245 KB

english, 2011

21

Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease

Mitchell, Claudia, Mahrouf-Yorgov, Meriem, Mayeuf, Alicia, Robin, Marie-Anne, Mansouri, Abdellah, Fromenty, Bernard, Gilgenkrantz, Hélène

Journal:

Laboratory Investigation

Année:

2010

Langue:

english

Fichier:

PDF, 665 KB

english, 2010

22

β-Aminoisobutyric Acid Prevents Diet-induced Obesity in Mice With Partial Leptin Deficiency

Karima Begriche, Julie Massart, Adjé Abbey-Toby, Anissa Igoudjil, Philippe Lettéron, Bernard Fromenty

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2008

23

Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver

Abdellah Mansouri, Delphine Haouzi, Véronique Descatoire, Christine Demeilliers, Angela Sutton, Nathalie Vadrot, Bernard Fromenty, Gérard Feldmann, Dominique Pessayre, Alain Berson

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 318 KB

english, 2003

24

Inhibition of microsomal triglyceride transfer protein: Another mechanism for drug-induced steatosis in mice

Philippe Lettéron, Angela Sutton, Abdellah Mansouri, Bernard Fromenty, Dominique Pessayre

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 200 KB

english, 2003

25

Fulminant hepatitis after grand mal seizures: Mechanisms and role of liver transplantation

Philippe Ichai, Emmanuel Huguet, Catherine Guettier, Daniel Azoulay, Maria Eugenia Gonzalez, Bernard Fromenty, Pascal Masnou, Faouzi Saliba, Bruno Roche, Fahed Zeitoun, Denis Castaing, Didier Samuel

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 137 KB

english, 2003

26

Efficient and specific amplification of identified partial duplications of human mitochondrial DNA by long PCR

Bernard Fromenty, Giovanni Manfredi, James Sadlock, Lee Zhang, Michael P. King, Eric A. Schon

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Année:

1996

Langue:

english

Fichier:

PDF, 872 KB

english, 1996

27

Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates

Isabelle Larosche, Amal Choumar, Bernard Fromenty, Philippe Lettéron, Adjé Abbey-Toby, Holly Van Remmen, Charles J. Epstein, Arlan Richardson, Gérard Feldmann, Dominique Pessayre, Abdellah Mansouri

Journal:

Toxicology and Applied Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 1.60 MB

english, 2009

28

Evaluation of drug toxicity using isolated mouse liver mitochondria

Annie Borgne-Sanchez, Mathieu Porceddu, Nelly Buron, Bernard Fromenty

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2010

Langue:

english

Fichier:

PDF, 70 KB

english, 2010

29

Increased Susceptibility to Liver Fibrosis with Age Is Correlated with an Altered Inflammatory Response

Mahrouf-Yorgov, Meriem, de l'Hortet, Alexandra Collin, Cosson, Claudine, Slama, Abdelhamid, Abdoun, Elsa, Guidotti, Jacques-Emmanuel, Fromenty, Bernard, Mitchell, Claudia, Gilgenkrantz, Hélène

Journal:

Rejuvenation Research

Année:

2011

Langue:

english

Fichier:

PDF, 690 KB

english, 2011

30

Tianeptine, a new tricyclic antidepressant metabolized by β-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice

Bernard Fromenty, Eric Freneaux, Gilles Labbe, Dominique Deschamps, Dominique Larrey, Philippe Letteron, Dominique Pessayre

Journal:

Biochemical Pharmacology

Année:

1989

Langue:

english

Fichier:

PDF, 755 KB

english, 1989

31

Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice: Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant

Philippe Lettéron, Gilles Labbe, Claude Degott, Alain Berson, Bernard Fromenty, Marcel Delaforge, Dominique Larrey, Dominique Pessayre

Journal:

Biochemical Pharmacology

Année:

1990

Langue:

english

Fichier:

PDF, 907 KB

english, 1990

32

Effects of various tetracycline derivatives on in vitro and in vivo β-oxidation of fatty acids, egress of triglycerides from the liver, accumulation of hepatic triglycerides, and mortality in mice

Gilles Labbe, Bernard Fromenty, Eric Freneaux, Veronique Morzelle, Philippe Letteron, Alain Berson, Dominique Pessayre

Journal:

Biochemical Pharmacology

Année:

1991

Langue:

english

Fichier:

PDF, 302 KB

english, 1991

33

Generation of free radicals during the reductive metabolism of nilutamide by lung microsomes: Possible role in the development of lung lesions in patients treated with this anti-androgen

Virginie Berger, Alain Berson, Claude Wolf, Claude Chachaty, Daniel Fau, Bernard Fromenty, Dominique Pessayre

Journal:

Biochemical Pharmacology

Année:

1992

Langue:

english

Fichier:

PDF, 501 KB

english, 1992

34

Evaluation of human blood lymphocytes as a model to study the effects of drugs on human mitochondria: Effects of low concentrations of amiodarone on fatty acid oxidation, ATP levels and cell survival

Bernard Fromenty, Philippe Letteron, Cecile Fisch, Alain Berson, Dominique Deschamps, Dominique Pessayre

Journal:

Biochemical Pharmacology

Année:

1993

Langue:

english

Fichier:

PDF, 1.35 MB

english, 1993

35

Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes

Marie-Anne Robin, Ingrid Sauvage, Thomas Grandperret, Véronique Descatoire, Dominique Pessayre, Bernard Fromenty

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 368 KB

english, 2005

36

NASH: a mitochondrial disease

Dominique Pessayre, Bernard Fromenty

Journal:

Journal of Hepatology

Année:

2005

Langue:

english

Fichier:

PDF, 666 KB

english, 2005

37

High hepatic glutathione stores alleviate Fas-induced apoptosis in mice

Sophie Cazanave, Alain Berson, Delphine Haouzi, Nathalie Vadrot, Daniel Fau, Alain Grodet, Philippe Lettéron, Gérard Feldmann, Jamel El-Benna, Bernard Fromenty, Marie-Anne Robin, Dominique Pessayre

Journal:

Journal of Hepatology

Année:

2007

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2007

38

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

Karima Begriche, Julie Massart, Marie-Anne Robin, Annie Borgne-Sanchez, Bernard Fromenty

Journal:

Journal of Hepatology

Année:

2011

Langue:

english

Fichier:

PDF, 3.66 MB

english, 2011

39

Mitochondria are sensors for HIV drugs

Frédéric Petit, Bernard Fromenty, Andrew Owen, Jérôme Estaquier

Journal:

Trends in Pharmacological Sciences

Année:

2005

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2005

40

High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes

Anissa Igoudjil, Julie Massart, Karima Begriche, Véronique Descatoire, Marie-Anne Robin, Bernard Fromenty

Journal:

Toxicology in Vitro

Année:

2008

Langue:

english

Fichier:

PDF, 490 KB

english, 2008

41

Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen

Laetitia Knockaert, Véronique Descatoire, Nathalie Vadrot, Bernard Fromenty, Marie-Anne Robin

Journal:

Toxicology in Vitro

Année:

2011

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2011

42

Low doses of water pharmaceutical contaminants disturb hepatic gene expression in mice

Sébastien Anthérieu, Marie-Anne Robin, Bernard Fromenty

Journal:

Toxicology Letters

Année:

2012

Langue:

english

Fichier:

PDF, 86 KB

english, 2012

43

Protection against Hepatocyte Mitochondrial Dysfunction Delays Fibrosis Progression in Mice

Claudia Mitchell, Marie-Anne Robin, Alicia Mayeuf, Meriem Mahrouf-Yorgov, Abdellah Mansouri, Marie Hamard, Dominique Couton, Bernard Fromenty, Hélène Gilgenkrantz

Journal:

The American Journal of Pathology

Année:

2009

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2009

44

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells

Anthérieu, Sébastien, Azzi, Pamela Bachour-El, Dumont, Julie, Abdel-Razzak, Ziad, Guguen-Guillouzo, Christiane, Fromenty, Bernard, Robin, Marie-Anne, Guillouzo, André

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 2.26 MB

english, 2013

45

Most cases of medium-chain acyl-CoA dehydrogenase deficiency escape detection in France

Bernard Fromenty,Abdellah Mansouri,Jean-Paul Bonnefont…

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 17 KB

english, 1996

46

Possible role of HLA in hepatotoxicity: An exploratory study in 71 patients with drug-induced idiosyncratic hepatitis

Alain Berson, Eric Fréneaux, Dominique Larrey, Virginia Lepage, Corinne Douay, Christine Mallet, Bernard Fromenty, Jean-Pierre Benhamou, Dominique Pessayre

Journal:

Journal of Hepatology

Année:

1994

Langue:

english

Fichier:

PDF, 547 KB

english, 1994

47

Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice

Philippe Lettéron, Bernard Fromenty, Terris Benoît, Claude Degott, Dominique Pessayre

Journal:

Journal of Hepatology

Année:

1996

Langue:

english

Fichier:

PDF, 1.29 MB

english, 1996

48

Assessment of the prevalence of genetic metabolic defects in acute fatty liver of pregnancy

Abdellah Mansouri, Bernard Fromenty, François Durand, Claude Degott, Jacques Bernuau, Dominique Pessayre

Journal:

Journal of Hepatology

Année:

1996

Langue:

english

Fichier:

PDF, 124 KB

english, 1996

49

Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients

Abdellah Mansouri, Bernard Fromenty, Alain Berson, Marie-Anne Robin, Sylvie Grimbert, Michel Beaugrand, Serge Erlinger, Dominique Pessayre

Journal:

Journal of Hepatology

Année:

1997

Langue:

english

Fichier:

PDF, 820 KB

english, 1997

50

Impaired mitochondrial function in microvesicular steatosis effects of drugs, ethanol, hormones and cytokines

Bernard Fromenty, Dominique Pessayre

Journal:

Journal of Hepatology

Année:

1997

Langue:

english

Fichier:

PDF, 1.35 MB

english, 1997